Département de
Biologie Moléculaire

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, Almusa H, Robyr D, Guipponi M, Saarela J, Gorgoulis VG, Antonarakis SE, Halazonetis TD

Cancer Res 2012 Dec 1;72(23):6279-89

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The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.

Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gagos S, Halazonetis TD

Carcinogenesis 2012 Jun;33(6):1203-10

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Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.

Dereli-Öz A, Versini G, Halazonetis TD

Mol Oncol 2011 Aug;5(4):308-14

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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.

Petty TJ, Emamzadah S, Costantino L, Petkova I, Stavridi ES, Saven JG, Vauthey E, Halazonetis TD

EMBO J 2011 Jun 1;30(11):2167-76

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Genomic instability in induced stem cells.

Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD

Cell Death Differ 2011 May;18(5):745-53

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TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.

Cescutti R, Negrini S, Kohzaki M, Halazonetis TD

EMBO J 2010 Nov 3;29(21):3723-32

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Genomic instability--an evolving hallmark of cancer.

Negrini S, Gorgoulis VG, Halazonetis TD

Nat Rev Mol Cell Biol 2010 Mar;11(3):220-8

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Emerging common themes in regulation of PIKKs and PI3Ks.

Lempiäinen H, Halazonetis TD

EMBO J 2009 Oct 21;28(20):3067-73

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An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.

Zgheib O, Pataky K, Brugger J, Halazonetis TD

Mol Cell Biol 2009 Feb;29(4):1050-8

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An oncogene-induced DNA damage model for cancer development.

Halazonetis TD, Gorgoulis VG, Bartek J

Science 2008 Mar 7;319(5868):1352-5

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Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.

Venere M, Snyder A, Zgheib O, Halazonetis TD

Cancer Res 2007 Jul 1;67(13):6100-5

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG

Nature 2006 Nov 30;444(7119):633-7

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD

Nature 2005 Apr 14;434(7035):907-13

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD

Nature 2004 Nov 18;432(7015):406-11

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Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD

Structure 2004 Jul;12(7):1237-43

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