Halazonetis Lab

Selected Papers [ Show all publications ]

2018

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
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Nature, ; 555 (7694): 112-116

2017

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue.
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Cell Rep, ; 19 (11): 2185-2192

2016

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.
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Mol Cell, ; 64 (6): 1127-1134
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication.
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EMBO Rep, ; 17 (12): 1731-1737

2015

2014

Break-induced replication repair of damaged forks induces genomic duplications in human cells.
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Science, ; 343 (6166): 88-91

2013

Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
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Nat Commun, ; 4 1779

2012

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
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Cancer Res, ; 72 (23): 6279-6289

2011

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
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EMBO J, ; 30 (11): 2167-2176

2010

Genomic instability--an evolving hallmark of cancer.
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Nat Rev Mol Cell Biol, ; 11 (3): 220-228

2008

2006

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
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Nature, ; 444 (7119): 633-637

2005

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
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Nature, ; 434 (7035): 907-913

2004

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
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Nature, ; 432 (7015): 406-411